Regia: Anthony Russo, Joe Russo

Attori: Scarlett Johansson - Natasha Romanoff/Vedova Nera, Karen Gillan - Nebula, Chris Hemsworth - Thor, Tom Hiddleston - Loki, Elizabeth Olsen - Wanda Maximoff/Scarlet Witch, Tom Holland (II) - Peter Parker/Spider-Man, Chris Pratt - Peter Quill/Star-Lord, Benedict Cumberbatch - Dott. Stephen Strange, Mark Ruffalo - Bruce Banner/Hulk, Zoe Saldana - Gamora, Pom Klementieff - Mantis, Robert Downey Jr. - Tony Stark/Iron Man, Jeremy Renner - Clint Barton/Occhio di falco, Josh Brolin - Thanos, Sebastian Stan - Bucky Barnes/Winter Soldier, Chris Evans - Steve Rogers, Dave Bautista - Drax, Jon Favreau - Happy Hogan, Benicio Del Toro - The Collector, Paul Rudd - Scott Lang/Ant-Man, Chadwick Boseman - T'Challa/Black Panther, Gwyneth Paltrow - Pepper Potts, Paul Bettany - Vision, Danai Gurira - Okoye, Anthony Mackie - Sam Wilson/Falcon, Don Cheadle - James Rhodes/War Machine, Benedict Wong - Wong, Letitia Wright - Shuri, Tiffany Espensen - Cindy, Winston Duke - M'Baku, Isabella Amara - Sally, Tom Vaughan-Lawlor - Ebony Maw

Soggetto: Jack Kirby - (fumetti), Jim Starlin - (fumetti)

Sceneggiatura: Christopher Markus, Stephen McFeely

Fotografia: Trent Opaloch

Musiche: Alan Silvestri

Montaggio: Matthew Schmidt, Jeffrey Ford

Scenografia: Charles Wood

Arredamento: Leslie A. Pope

Costumi: Judianna Makovsky

Effetti: Daniel Sudick, Gerardo Aguilera, Dan DeLeeuw, Russell Earl, Jamie Hallett, Greg Steele, Cinesite, Capital T, Clear Angle Studios, Digital Domain, Legacy Effects, Weta Digital Ltd., Method Studios, Industrial Light & Magic (ILM), Framestore, Direct Dimensions (DDI), Double Negative, Elstree Effects, Territory Studio